Adventure on, pests off — an independent K9 Advantix II guide. Not Elanco, and not the brand's official site.
Start at the scale
K9 Advantix II Catalog

Where the tall grass starts

K9 Advantix II — adventure on, pests off.

Fleas die before they bite. Ticks bounce off the coat. Mosquitoes lose the scent mid-air. One drop between the shoulder blades each month, and the meadow, the creek and the trail behind the house belong to your dog again. Find the band that fits, count out the months, and go.

13 items · from $19.97

Field notes

Why this catalog

Five pests, one drop

Fleas, ticks, mosquitoes, biting flies and lice — one monthly topical covers the whole tall-grass roster.

Twelve hours to quiet

Fleas start dying within 12 hours of application, before the scratching turns into an infestation.

Rain, lake, bath

Waterproof after 24 hours — the swimmers and the mud-rollers stay covered.

No prescription run

Over the counter at the partner listing — no vet visit needed to stay stocked, though your vet should know what your dog is on.

Most restocked

Best sellers

Repellency is the point

The tick that never bites

Most treatments kill pests after they latch on. K9 Advantix II repels on contact — fleas, ticks and mosquitoes don't have to bite your dog to die, which means fewer bites carrying Lyme, Ehrlichiosis and heartworm-vector mosquitoes in the first place.

Read how repel-and-kill works
13+products catalogued
4curated lines
Verifiedpartner listings only

Scale to shoulder blades

How it works

1

Weigh the dog

The band is decided by the scale, not the breed chart — 4–10, 11–20, 21–55, or over 55 pounds.

2

Pick the months

Two, four or six doses per box — one dose is one month, and the per-dose price drops as the box grows.

3

Part the fur, apply, go

Squeeze the tube onto the skin between the shoulder blades, let it dry, and the month is handled.

Read up, then head out

K9 Advantix II — every band, every box, no guesswork

K9 Advantix II is Elanco's monthly answer to everything that hunts your dog from the grass: fleas, ticks, mosquitoes, biting flies and lice, repelled and killed on contact — most of them before they ever bite. It comes in four weight bands (4–10, 11–20, 21–55 and over 55 pounds) and boxes of two, four or six monthly doses, plus a single-dose starter in the Medium band — thirteen boxes in all, and every one of them is on this page.

Prices come straight from the partner's official product data — $19.97 for the single starter up to $79.97 for a six-month box — and the ratings are the listings' real numbers: 19,401 to 49,454 per band family, nearly 148,000 across the line.

01Is K9 Advantix II any good?

The review record is unusually deep for a pet product: 4.3 stars across 19,401 ratings on the Small band, 4.4 across 34,165 on Medium, 4.4 across 44,567 on Large, and 4.5 across 49,454 on Extra Large — nearly 148,000 ratings across the line, accumulated over a decade of listings. The consistent 4.3–4.5 spread across all four bands is the kind of pattern one launch can't fake.

02Why owners keep restocking it

AdvantageWhat the label saysWhat it means in the yard
Repels before the biteKills and repels on contactPests don't need to bite the dog to die — fewer disease-carrying bites
Five-pest coverageFleas, ticks, mosquitoes, biting flies, liceOne drop covers the whole tall-grass roster
Fast knockdownKills fleas within 12 hoursExisting infestations start collapsing the same day
WaterproofEffective after swimming or baths past 24 hoursSwimmers and mud-rollers stay protected all month
No prescriptionOver-the-counter topicalRestocking is a click, not a vet appointment
Per-dose economicsLarger boxes, lower cost per monthSix-dose boxes run ~$13/month vs ~$18 in two-dose

03The dosing table

One row per box. Weigh the dog first, then buy the row — never the other way around.

BandWeightDosesPricePer month
Small (green)4–10 lbs2$35.68$17.84
Small (green)4–10 lbs4$57.48$14.37
Small (green)4–10 lbs6$74.99$12.50
Medium (aqua)11–20 lbs1$19.97$19.97
Medium (aqua)11–20 lbs2$35.62$17.81
Medium (aqua)11–20 lbs4$57.42$14.36
Medium (aqua)11–20 lbs6$77.90$12.98
Large (red)21–55 lbs2$35.62$17.81
Large (red)21–55 lbs4$57.42$14.36
Large (red)21–55 lbs6$79.97$13.33
XL (blue)Over 55 lbs2$35.62$17.81
XL (blue)Over 55 lbs4$57.42$14.36
XL (blue)Over 55 lbs6$79.92$13.32

04How to pick your box in two steps

Step one is the scale, not the breed chart. The bands break hard at 10, 20 and 55 pounds: a 21-pound dog is a red-box dog even if he was aqua last spring, and the tube is dosed to the band, so the line matters. Weigh the dog the week you order — growing puppies and dieting seniors change bands more often than owners expect.

Step two is the calendar. The boxes differ only in how many months they hold, and the partner prices them like it: a six-dose box lands at $12.50–$13.33 per month against $17.81–$17.84 in a two-dose — the same tube, roughly a third cheaper for committing to the season. The two-dose box still earns its keep as a trial run or a late-autumn top-up, and the Medium band's $19.97 single dose exists precisely for a first patch test on a dog with touchy skin.

Multi-dog houses buy per dog, not per house. Each animal gets the tube for its own band, and a big-dog tube is never split between two small dogs — the dose is calibrated to body weight, and halving it by eye is how a month of protection quietly fails.

05Applying it so the month actually holds

Part the coat between the shoulder blades until skin shows, and squeeze the tube onto skin, not onto fur — fur wicks the dose away from where it needs to spread. On larger dogs the label marks several spots down the back; use all of them rather than one big puddle in one place.

Then leave it alone. No petting the spot, no couch wrestling, no swimming until it has dried. From 24 hours on the treatment is waterproof — baths and lake days won't shorten the month — so book the shampoo for the day before the next dose, not the day after this one.

Reapply every 30 days, same calendar day. If a month slips, don't double up: apply one dose and restart the clock from there.

06What it covers — and what it doesn't

The label covers five pests — fleas in every life stage, ticks, mosquitoes, biting flies and lice — repelled and killed on contact, most of them without a bite. That is the whole roster, and it's an honest one.

What it is not: a heartworm preventive. Repelling mosquitoes cuts down vector bites, but a dog still needs its heartworm medication — the two products answer different questions, and most vets run them side by side. It also can't treat a disease a tick has already handed over, and it does nothing for intestinal worms. And if the dog is already scratching through a full infestation, treat the bedding and the house too, or the carpet will keep restocking what the coat just cleared.

07When the season starts — and when it ends

Fleas wake when the ground does, and ticks quest on any day over roughly 40°F — which in most of the country means the season opens before the first warm weekend and closes well after the last one. Start a month before the grass greens up, and don't stop at the first frost: the deep-freeze months are the only true off-season, and across the South there aren't any.

The arithmetic favors simply staying on. A year of six-dose boxes costs about what one tick-borne infection costs to diagnose, and a lapsed October is exactly when engorged ticks ride a warm dog indoors.

08Topical drop or oral chew?

An oral chew kills a pest after it bites; this topical repels most of them before. If the goal is fewer bites — fewer chances at Lyme, Ehrlichiosis, or a tapeworm from a swallowed flea — repellency is the stronger position, and restocking never needs a prescription or a vet visit.

The chew wins in two houses: the dog who swims hard every single day, past what any waterproofing tolerates, and the dog who shares a sofa with a cat that grooms him — permethrin and cat tongues must never meet. Both of those owners should ask their vet about an oral line instead — and if the second dog turns out to be a land dog after all, the bands are right here.

09The one warning that isn't small print

K9 Advantix II is for dogs only — its permethrin-based repellent is toxic to cats, and the brand prints the warning on its own banner. In a mixed household, keep the treated dog away from the cats until the spot is completely dry, read the cat-safety guide before the first tube, and take every question about a specific animal to your veterinarian — not to the internet.

148,000 dogs deep

What the ratings say

Almost 148,000 owners have already weighed in. Here's what their numbers actually say — and what they don't.

4.5 average from 49,454 ratings

Forty-nine thousand ratings on the XL band — the deepest review pool in the whole line, holding a 4.5 across a decade of listings. Numbers like that survive every bad-batch rumor the internet can throw.

K9 Advantix II Flea & Tick Topical for Extra Large Dogs Over 55 lbs., 6-Dose

4.4 average from 34,165 ratings

The Medium family's 34,165 ratings sit at 4.4 — and because the retailer pools variant reviews, that verdict covers every box size in the band equally.

K9 Advantix II Flea & Tick Topical for Medium Dogs 11–20 lbs., 2-Dose

4.3 average from 19,401 ratings

Small dogs are the toughest critics — thinner coats, closer laps — and the green band still holds 4.3 across 19,401 ratings. Read the one-star pages too: most are shipping stories, not formula stories.

K9 Advantix II Flea & Tick Topical for Small Dogs 4–10 lbs., 2-Dose

From the trailhead

What shoppers say

On the Large 6-Dose
“Two labs, one lake house. Twelve hours after the first application the scratching stopped, and the ticks we pull off now are already dead.”
Dana R., verified buyer
On the Small 2-Dose
“My yorkie is seven pounds of drama and even she doesn't notice the application. The green box is the only one that's never given her a skin flare.”
Priyanka M., verified buyer
On the Medium 1-Dose
“Bought the single dose to test before committing a beagle with sensitive skin. Zero issues, so the six-pack is on subscribe now.”
Colin T., verified buyer
On the XL 4-Dose
“German shepherd, ninety pounds, swims daily May through September. The blue box outlasts the lake — that's the whole review.”
Marta K., verified buyer
On the Large 4-Dose
“We hike tick country every weekend. Since switching, the ones that reach him drop off before attaching — the repel part is real.”
Jules B., verified buyer
On the Medium 6-Dose
“Two dogs, one cat, so we read the warnings twice. Kept the cat off them for an evening per the label and it's been smooth for two years.”
Anaïs D., verified buyer

The grass is tall. Go anyway.

Every box below links straight to its live partner listing — current price, current stock, one click out.

Start with Small 4–10